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If I have atrial fibrillation, do new oral anticoagulants (Xarelto, Pradaxa, Eliquis, Lixiana) reduce strokes but cause more stomach bleeding than warfarin?


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MedHead Message:

The bottom line here is this: Newer anticoagulants reduce strokes, but increase gastrointestinal bleeding in patients with atrial fibrillation. Overall, there may be a slight edge in safety over warfarin, but consider the cost per month. Typically you pay $5,000 per year more for the newer anticoagulants.


1. Ruff, Christian, et.al Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. The Lancet
Volume 383, Issue 9921, 15–21 March 2014, Pages 955-962


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