Unfortunately, there just isn’t enough data to confidently recommend SAM-e (s-adenosylmethionine) for the treatment of depression, either alone or in conjunction with other antidepressants. This may change as we get more data, but until then, we can’t make this recommendation.
“1. Sarris, J et al. Adjunctive S-adenosylmethionine (SAMe) in treating non-remittent major depressive disorder: An 8-week double-blind, randomized, controlled trial. European Neuropsychopharmacology
Volume 28, Issue 10, October 2018, Pages 1126-1136 2. Galizia I, Oldani L, Macritchie K, Amari E, Dougall D, Jones TN, Lam RW, Massei GJ, Yatham LN, Young AH. S‐adenosylmethionine (SAMe) for depression in adults. Cochrane Database of Systematic Reviews 2016, Issue 10. Art. No.: CD011286. DOI: 10.1002/14651858.CD011286.pub2.”