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Does Enbrel (Etanercept) work better than the traditional combination of methotrexate, Plaquenil (hydrochloroquine), and sulfasalzine for my rheumatoid arthritis symptoms?


MedHead Confidence Score: 5
Amount Saved: $4,846 cost per month for Enbrel post


MedHead Message:

Enbrel costs about $57,000 more per year than three medications that work just as well for Rheumatoid arthritis. At $57,000 per year, you could pay for your next entire family reunion in Hawaii!


1. Hazelwood GS, et. al. Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis. BMJ. 2016 Apr 21;353:i1777 2. Eriksson JK, et. al. Cost-effectiveness of infliximab versus conventional combination treatment in methotrexate-refractory early rheumatoid arthritis: 2-year results of the register-enriched randomised controlled SWEFOT trial. Ann Rheum Dis. 2015 Jun;74(6):1094-101 3. Bansback N, et. al. Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis.Ann Intern Med. 2017 Jul 4;167(1):8-16 4. Moreland, LW, et. al. A Randomized Comparative Effectiveness Study of Oral Triple Therapy versus Etanercept plus Methotrexate in Early, Aggressive Rheumatoid Arthritis. Arthritis Rheum. 2012 Sep; 64(9): 2824–2835.5. https://www.goodrx.com/remicade?drug-name=remicade


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