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Does chlorthalidone lower systolic blood pressure better than lisinopril or amlodipine?


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MedHead Message:

Chlorthalidone is the star here. It is cheap and works really well. Keep this in mind when starting medication. Alternatively, hydrochlorothiazide may be used the first line, and is more affordable, but is not quite as powerful as chlorthalidone.


1. ALLHAT collaborative research group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002 Dec 18;288(23):2981-97 2. https://www.goodrx.com/chlorthalidone?drug-name=chlorthalidone


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